Endocrine Abstracts

Objective: The search for the predictors of the Cushing’s disease (CD) recurrence after surgical treatment among the following parameters - gender, age, adenoma size, preoperative levels of ACTH (morning) and cortisol (evening) in the blood, postoperative levels of ACTH (morning) and cortisol (morning) in the blood.Material and methods: A retro- and prospective monocenter study of treatment outcomes in 181 patients with confirmed diagnosis of Cushin...

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

Background: Acromegaly is an orphan neuroendocrine disease characterized by a variety of complications. Due to slow symptom progression acromegalic patients often are involved in growth hormone complications correction for a long time instead of search for main cause of these multiple disorders. A view on conductive hearing loss in acromegaly in literature is contradictory. The low incidence of hearing in acromegaly, compared with other complications, is presumably due to the ...

Objectives: To evaluate predictors of permanent, transient and three-phase diabetes insipidus (DI) in patients undergoing endoscopic endonasal transsphenoidal surgery.Patients and methods: The study included 154 patients undergoing endoscopic endonasal transsphenoidal surgery (122 women and 32 men) age from 18 to 65 years (median 40 (31;52)). 73 patients with Cushing disease, 66 patients with acromegaly, four patients with prolactinomas, nine patients wi...

Objective: To assess the levels of osmolality, sodium in blood and urine, and copeptin level in patients after transnasal adenomectomy for pituitary adenomas.Materials and methods: A total of 154 patients, aged 18 to 65 years, were included in this study and underwent transnasal adenomectomy. Surgical treatment was performed in 73 patients with Cushing’s disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inact...

ObjectivesTo assess diagnostic and prognostic markers of permanent and transient postoperative diabetes insipidus.Patients and methodsThe study included 152 patients undergone endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40 [31; 52] years. Seventy three patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inactive adenoma, 1 –...

IntroductionThyrotropin-secreting pituitary adenomas (TSH-omas) are rare. For this reason each case of TSH-secreting pituitary tumor can help expand extensive clinical experience in world practice.Materials and methodsWe included 40 patients with TSH secreting pituitary adenomas. Hormonal profile: TSH (0.25-3.5 mIU/L), FT4 (9-20 pmol/l) FT3 (2.5-5.5 pmol/l) were measured by Architect i2000SR (Abbott Laborator...

IntroductionClinically functioning gonadotroph adenomas (FGA) are rare, especially in men. We present a case of a LH/FSH-secreting functioning gonadotroph macroadenoma in an elderly patient, which manifested with visual impairment and was accompanied by secondary erythrocytosis.Clinical caseA 62-y.o. male was admitted to our hospital with a 9-month history of visual impairment and a 5-year history of plethora...

Objectives: To assess the frequencies of hyponatremia and central diabetes insipidus (CDI) after transnasal adenomectomy and to identify its risk factors.Patients and methods: The study included 152 patients aged 18 to 65 years (median [Q1; Q3] 40 [31; 52]) who underwent endoscopic endonasal transsphenoidal surgery due to Cushing’s disease, acromegaly, prolactinoma, non-functioning pituitary adenoma, thyreotropinoma or Nelson’s syndrome at Endo...

Introduction: Water-electrolyte disorders are serious complications after transnasal adenomectomy for formations of the hypothalamic-pituitary region. The purpose of this work was to evaluate the incidence of postoperative hyponatremia in the tactics of active control of sodium levels in the blood.Materials and methods: The study included the results of a dynamic study of blood sodium levels in 53 patients (mean age 46.6 years [min 19; max 68]) with pitu...